MARC状态：待编 文献类型：西文图书 浏览次数：22
- 题名/责任者:
- Chromatin Accessibility: Methods And Protocols
- 出版发行项:
- Humana 2024.
- ISBN:
- 9781071629017
- 载体形态项:
- 341 p..
- 变异题名:
- 染色质可访问性：方法与协议
- 中图法分类号:
- Q3
- 摘要附注:
- This detailed volume provides a comprehensive resource covering the existing and state-of-the-art tools in the field of profiling chromatin accessibility and its dynamics. Beginning with a section on bulk-cell methods for profiling chromatin accessibility and nucleosome positioning that rely on enzymatic cleavage of accessible DNA and produce information about relative accessibility, the book continues with methods that use single-molecule and enzymatic approaches to solving the problem of mapping absolute occupancy/accessibility, emerging tools for mapping DNA accessibility and nucleosome positioning in single cells, imaging-based methods for visualizing accessible chromatin in its nuclear context, as well as computational methods for the processing and analysis of chromatin accessibility datasets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
- 随书光盘:
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