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- 000 02530cam a2200385 a 4500
- 008 101015s2011 njua b 001 0 eng
- 020 __ |a 9780470449820 (cloth) : |c CNY820.00
- 020 __ |a 9781118001042 (oBook)
- 020 __ |a 9781118001035 (ePDF)
- 020 __ |a 9781118008980 (ePub)
- 040 __ |a DNLM/DLC |c DLC |d YDX |d NLM |d YDXCP |d CDX |d DLC
- 050 00 |a RA1224.3 |b .A679 2011
- 099 __ |a CAL 022011369561
- 245 00 |a Applications of toxicogenomics in safety evaluation and risk assessment / |c edited by Darrell R. Boverhof, B. Bhaskar Gollapudi.
- 260 __ |a Hoboken, N.J. : |b John Wiley & Sons, |c c2011.
- 300 __ |a xiii, 377 p., [8] p. of plates : |b ill. (some col.) ; |c 25 cm.
- 504 __ |a Includes bibliographical references and index.
- 505 0_ |a Toxicology, "omics" technologies, and toxicogenomics : a primer -- Introduction to human health risk assessment -- Practical considerations for the application of toxicogenomics to risk assessment -- early experience, current drivers, and a path forward -- Approaches and practical considerations for the analysis of toxicogenomics data -- Genomics in identifying mutagenic mode of action in carcinogenesis -- Application of genomics for predicting and understanding the mode of action for non-genotoxic carcinogens -- Genomics in characterizing endocrine toxicity -- Studying organ specific toxicity using gene expression profiling -- Toxicogenomic studies in human populations -- Toxicogenomics applied to ecological risk assessment -- Analysis of transcriptomic dose response data for toxicology and risk assessment -- Toxicogenomics as a tool for validating animal to human extrapolations in chemical risk assessment: concepts, applications and challenges -- Toxicogenomics and animal alternatives -- Toxicogenomics and the regulatory framework -- Standardization of gene expression information for the safety evaluation -- activities in Japan -- Applying transcriptional profiling in drug safety evaluation -- Reframing the risk assessment paradigm : towards a systems biology approach.
- 650 _0 |a Genetic toxicology.
- 650 _0 |a Toxicity testing.
- 650 _0 |a Health risk assessment.
- 650 12 |a Toxicogenetics.
- 650 22 |a Risk Assessment.
- 700 1_ |a Boverhof, Darrell R.
- 700 1_ |a Gollapudi, B. Bhaskar.