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• 000 01462cam a2200361 a 4500

• 001 0000417851

• 005 20131206084100.0

• 008 120709s2013 enka b 001 0 eng

• 010 __ |a 2012027613

• 020 __ |a 9781107008809 (hardback) : |c CNY784.00

• 020 __ |a 9781107401358 (pbk.)

• 040 __ |a DNLM/DLC |c DLC |d DLC

• 042 __ |a pcc

• 050 00 |a R853.C55 |b G46 2013

• 060 10 |a QU 58.5

• 082 00 |a 610.72/4 |2 23

• 090 __ |a R4/SRM/ED-11

• 093 __ |a R4 |2 5

• 099 __ |a CAL 022013066326

• 100 1_ |a Simon, Richard M., |d 1943-

• 245 10 |a Genomic clinical trials and predictive medicine / |c Richard M. Simon.

• 260 __ |a Cambridge : |b Cambridge University Press, |c 2013.

• 300 __ |a xiii, 144 p. : |b ill. ; |c 26 cm.

• 490 0_ |a Practical guides to biostatistics and epidemiology

• 504 __ |a Includes bibliographical references (p. [129]-138) and index.

• 505 0_ |a Clinical trial basics -- Actionable prognostic biomarkers -- Phase II designs -- Enrichment designs -- Including both test positive and test negative patients -- Adaptive threshold design -- Multiple predictive biomarkers predictive analysis of clinical trials -- Prospective : retrospective design.

• 650 12 |a Clinical Trials as Topic |x methods.

• 650 12 |a Genomics |x methods.

• 650 22 |a Individualized Medicine |x methods.

• 650 22 |a Neoplasms |x genetics.

• 650 22 |a Research Design.

• 650 22 |a Tumor Markers, Biological |x genetics.

• 920 __ |a 211180 |z 2